You’ve heard about NAD+. Here’s how to actually use it.
NAD+ drops 50% by age 60. Halo prescribes, measures, and restores it — monthly, at home.
- A prescribed therapy — not a drugstore supplement.
- Subcutaneous injection — skip the IV chair.
- Paired with Glutathione. Monitored every 90 days.
Founding members from $145/mo. Free physician consultation before any prescription.
Halo \u00B7 Sample
Cellular Panel
NAD+ Level
LOWPhysician review \u00B7 90-day recheck
Halo 2026
Tap “90 days” to see the shift
Illustrative protocol targets · individual results vary
The science
NAD+ runs your mitochondria. And it’s running out.
NAD+ is the coenzyme your cells use to convert fuel into ATP and activate sirtuins for DNA repair. Tissue NAD+ declines roughly 50% between age 30 and 60 — a decline correlated with slower recovery, reduced mitochondrial output, and increased oxidative stress. Massudi et al., J Biol Chem, 2012.
0%
decline in tissue NAD+ between the third and seventh decades of life.
Massudi et al., PLOS ONE, 2012
0%
increase in whole-blood NAD+ with oral NAD+ precursor (NR) supplementation in healthy middle-aged and older adults.
Martens et al., Nature Communications, 2018
Your number
See roughly where you stand. Before you measure it.
Seven quick questions. One estimated cellular age. It’s not a diagnostic — Halo’s baseline panel is. But it’s a fast way to see how far the curve has moved on you.
Cellular Age Estimator
1 / 7
Question 1 of 7 · Your age
How old are you, chronologically?
years
What we measure before prescribing
Cellular energy is measurable. Most clinics never look.
What changes
The body responds faster. The mind starts sharper.
Hover or tap. See what shifts.
How it’s delivered
Three paths to the same molecule. Only one fits your life.
IV drips in a clinic chair. Subcutaneous injection at home. Oral capsules with lower bioavailability. Here’s how they stack up.
IV Clinic
In-office drip
Halo
Weekly at home
Oral
NR / NMN capsule
The protocol
What’s in your shipment. And why.
NAD+ Injection
100 mg, weekly subcutaneous
Direct NAD+ supplementation. Bypasses the gut. Reaches cellular targets efficiently.
Glutathione
200 mg, paired weekly
Antioxidant cofactor. NAD+ redox cycling increases oxidative load; Glutathione buffers it.
Baseline Lab Panel
16+ biomarkers
Metabolic, inflammation, and energy markers. Confirms you’re a candidate before any prescription.
90-Day Follow-up
Repeat panel
Your physician adjusts dose based on response. Protocol evolves with your labs.
Why the molecule matters
Not a lifespan claim. A biochemistry one.
Mitochondria
Cellular energy
NAD+ is the cofactor your mitochondria use to turn food into ATP. When NAD+ drops, the energy-production machinery slows.
DNA repair
PARP pathway
PARP enzymes use NAD+ to repair daily oxidative damage to DNA. Declining NAD+ means declining repair throughput.
Sirtuins
Metabolic regulation
Sirtuin enzymes regulate cellular stress response and metabolic health — and they're strictly NAD+-dependent.
NAD+ is a cofactor in over 500 known enzymatic reactions. Halo positions NAD+ therapy as metabolic substrate support, not as treatment for any specific disease. Compounded NAD+ is not FDA-approved.
The research
The work this rests on.
The clinical foundation for NAD+ therapy dates to discoveries by Charles Brenner (Dartmouth, now City of Hope), who identified the nicotinamide riboside (NR) salvage pathway in 2004. Since then, clinical work including Martens et al. (Nature Communications, 2018) has shown NR can raise whole-blood NAD+ by ~40% in healthy middle-aged adults.
Mechanistic research by Eric Verdin (Buck Institute) and David Sinclair (Harvard Medical School) has linked sirtuin activation to DNA repair, mitochondrial biogenesis, and metabolic regulation. Brakedal et al. (Cell Metabolism, 2022) demonstrated clinical benefit of NR supplementation in Parkinson’s disease populations.
Halo cites this research because it’s the honest foundation for NAD+ therapy. We don’t claim endorsement. We don’t promise lifespan extension. We provide a physician-led protocol grounded in peer-reviewed mechanism.
Your physician
A peptide and longevity specialist.Not a drip-clinic concierge.
Halo physicians are board-certified internists with specific training in peptide therapy, NAD+ protocols, and side-effect management.
Terms
From $145/mo for founding members. Everything in.
Full protocol · No contracts
What’s included
- Initial physician consultation
- Baseline metabolic + NAD-relevant panel
- NAD+ 100mg weekly subcutaneous injection
- Glutathione 200mg paired weekly
- Follow-up labs at 90 days
- Async physician access
- Injection supplies and shipping
No contracts. Cancel anytime.
Questions
Everything worth asking.
Adults 30 and over who want to slow cellular aging, improve recovery, and maintain metabolic resilience. It’s not a fatigue treatment — if your primary complaint is tiredness, your physician will screen for thyroid, iron, sleep, and cortisol first. NAD+ is for people whose labs indicate cellular-energy decline.
Same molecule. Same pharmacy grade. Different delivery. IV therapy ties you to 2–4 hour sessions at $600–$800 each. Halo sends you a weekly subcutaneous injection you self-administer at home in about 10 seconds. Bioavailability is comparable (~95% vs ~100%). Lab monitoring is included, which IV clinics rarely offer.
Oral precursors (NR, NMN) have real research behind them, but bioavailability is roughly 30–50% due to first-pass metabolism. Subcutaneous NAD+ bypasses the gut and liver, reaching cellular targets more efficiently. More importantly, Halo runs a full metabolic panel to confirm you’re a candidate and adjusts your protocol based on follow-up labs. Supplement brands can’t.
NAD+ 100mg subcutaneous weekly, paired with Glutathione 200mg as antioxidant cofactor (NAD+ redox cycling increases oxidative load; Glutathione buffers it). Baseline metabolic panel. Follow-up labs at 90 days. Physician async access throughout. Injection supplies and shipping included.
Most common: mild injection site redness or bruising, occasional headache during the first few doses. Rare: nausea, flushing, sleep disturbance. Not appropriate during active chemotherapy or with known B3-family allergies. Your physician screens for contraindications before prescribing.
NAD+ decline with age is well-documented (Massudi et al., J Biol Chem 2012). NR/NMN precursors have been shown to raise whole-blood NAD+ 40–60% in healthy adults (Martens et al., Nature Communications 2018). Halo positions NAD+ as metabolic resilience support, not a cure for any disease. We make no lifespan claims.
This depends on your baseline labs and how fast your body rebuilds substrate pools. In human trials of NAD+ precursor supplementation, blood NAD+ levels rise within weeks (Martens 2018); subjective effects are harder to predict and peer-reviewed trials have been mixed. Halo's position: we measure whether your labs move and your physician decides what that means. We don't promise you'll feel a specific thing by a specific date.
Yes. No contracts. Cancel through your member portal or by emailing your care team. Your prescription continues through the current shipment cycle.
Aging isn’t optional. The drift is.
Take on Father Time.
Founding members from $145/mo. Free physician consultation before any prescription. Cancel anytime.
Start my assessmentHalo is a technology platform that connects patients with licensed healthcare providers. All clinical decisions are made by independent licensed providers. Individual results vary. Not medical advice. Compounded drug products are not FDA-approved or evaluated. NAD+ therapy is not intended to diagnose, treat, cure, or prevent any disease, and Halo makes no lifespan claims. Rx required. Not available in all 50 states.